Those Nucleoside Analogues II — Remdesivir

By Nana Dadzie Ghansah

From Luděk Eyer et al. Antiviral Chemistry & Chemotherapy, March 2018.

Around 2009, the company Gilead Sciences developed a whole slew of nucleoside analogues (NAs) for use as possible antivirals and anti-cancer drugs. One of these NAs was given the name GS-5734. It was analogous to the nucleotide adenosine. Shortly after it was made, it was found to inhibit the viral RNA polymerases of a host of viruses — Hepatitis C, Yellow and Dengue…